PERSONAL EXPERIENCE
Dr. Li got Ph.D at Institute of High Energy physics, Chinese Academy of Sciences. In 2007, he was an Assistant professor at Institute of High Energy physics, Chinese Academy of Sciences.
RESEARCH INTRODUCTION
The relationship between environment and human health is a very critical issue and needs more and more effects to elucidate it. Currently, Dr. Li is major interested in the following two area of environment and health relationship study
1. Health effect of heavy metals exposure, especially mercury exposure and the corresponding health promotion study.
One of our major study area is Guizhou, where is rich in Hg. We have successfully implemented a pilot study on the selenium supplementation study in long-term mercury exposed populations in Guizhou (Phase I). A random double-blind controlled selenium intervention trials (phase II) will soon be performed as scheduled. The health effect of Se in long-term Hg exposed population will be investigated and the mechanism of Se and Hg interaction will also be elucidated.
We have investigated the mercury speciation and mercury biomolecules interaction using MALDI-TOF-MS, XAFS, and HPLC-ICP-MS. Synchrotron-based spectroscopic and microscopic methods, including X-ray absorption fine structure (XAFS), and X-ray fluorescent (XRF) in Beijing Synchrotron Radiation Facility (BSRF), China and KEK, Japan as a powerful techniques will also be used. Biological analysis like enzyme activity, DNA oxidation damage etc will also be investigated. Trace element determination and speciation study is also necessary.
Cooperation on the health effect of Hg-exposure and the corresponding health promotion study has been found with hospitals and other research institutes..
2. Health effect of artificial nanomaterials and the corresponding health promotion study.
More and more health concern on artificial nanomaterials is raised and a lot of animal and molecular experiments have shown the impact of artificial nanomaterials on health. Based on these studies, the health effect on human being of artificial nanomaterials will be studied and the corresponding health promotion measures will be studied.
REPRESENTATIVE PUBLICATIONS
1.Zhang T, Gao YX., Li B., Li YF, Chen CY, Wu G. Study of selenium species in selenized rice using high performance liquid chromatography-inductively coupled plasma-mass spectrometry. Chin. J. Anal. Chem., 2008, 36(2): 206-210.
2.Li YF, Chen CY, Li B, Li W, Qu LY, Dong ZQ, Nomura M, Gao YX, Zhao JX, Zhao YL and Chai ZF. Mercury in human hair and blood samples from people living in Wanshan mercury mine area, Guizhou, China: an XAS study, J. Inorg. Biochem. 2008, 102(3), 500-506.
3.Li YF, Chen CY, Li B, Wang JX, Gao YX, Zhao YL, and Chai ZF. Scalp hair as a biomarker in environmental and occupational mercury exposed populations: suitable or not, Environ. Res. 2007, doi:10.1016/j.envres.2007.07.003.
4.Li YF, Chen CY, Li B, Wang Q, Wang JX, Gao YX, Zhao YL and Chai ZF. Simultaneous speciation of selenium and mercury in human urine samples from long-term mercury-exposed populations with supplementation of selenium-enriched yeast by HPLC-ICP-MS. J. Anal. At. Spectrom., 2007, 22, 925-930.
5.Li YF, Li B, Wang JX, Jia G, Wang TC, Yan L, Qu LY. Study on increased urinary 8-OHdG in populations with long-term exposure to mercury. Chin. J Prevent. Med., 2007, 41(3), 236-237.
6.Wang JX, Li YF, Zhou GQ, Li B, Jiao F, Chen CY, Gao YX, Zhao YL, Chai ZF. Influence of intranasal instilled titanium dioxide nanoparticles on monoaminergic neurotransmitters of female mice under different exposure time. Chin. J Prevent. Med. 2007, 41(1), 91-95.
7.Sun J, Chen CY, Li YF, Li B, Gao YX, Chai ZF. Rapid Analysis of Methylmercury and Total mercury in biological samples by ultrasonic- assisted solvent extraction coupled with inductively coupled plasma-mass spectrometry. Spectrosc. Spectr. Anal., 2007, 27(1), 173- 176.
8.Li YF, Chen CY, Li B, Sun J, Wang JX, Gao YX, Zhao YL and Chai ZF. Elimination efficiency of different reagents for the memory effect of mercury using ICP-MS. J. Anal. At. Spectrom., 2006, 21(1), 94-96.
9.Wang JX, Chen C, Li B, Yu HW, Zhao YL, Sun J, Li YF, Xing GM, Yuan H, Tang J, Chen Z, Meng H, Gao YX, Ye C, Chai ZF, Zhu C, Ma B, Fang X, Wan L. Antioxidative function and biodistribution of [Gd@C82(OH)22]n nanoparticles in tumor-bearing mice. Biochem. Pharmacol. 2006, 71(6), 872-881.
10.Sun J, Chen CY, Li YF, Li B, Gao YX, Chai ZF. Analysis of total mercury and methylmercury concentrations in four commercially important freshwater fish species obtained from Beijing markets. J. Hygiene Res., 2006, 11,722-725.
11.Li YF, Chen CY, Xing L, Liu T, Xie YN, Gao YX, Li B, Qu LY, Chai ZF. Concentrations and XAFS speciation in situ of mercury in hair from populations in Wanshan mercury mine area, Guizhou Province. Nucl. Tech., 2004, 27(12), 899-903.
12.Li YF, Zhang TL, Zhang JG. Thermal decomposition processes and non-isothermal kinetics of KDNBF. Energ. Mater., 2004, 12(4), 203-206.
13.Li YF, Zhang TL, Zhang JG, Ma GX, Song JC, Yu KB. Preparation, crystal structure and thermal decomposition mechanism of [K(HTNR)(H2O)]n. Acta Chim. Sinica, 2003, 61(7), 1020-1024.
14.Li YF,Zhang TL, Zhang JG, Ma GX, Song JC, Sun YH, Yu KB. Preparation, molecular structure and thermal decomposition mechanism of [K2 (TNR) (H2O)]n. Chin. J. Inorg. Chem., 2003, 19(8), 861-864.
15.Li YF, Zhang TL, Zhang JG. Molecular structure and thermal analysis of potassium hydrogenphthalate monohydrate. Z. Naturforsch. B, 2003, 58, 1171-1175.
16. Li YF, Zhang TL, Zhang JG, Miao YL. A new way to synthesize spherical KDNBF. Chin. J. Expl. Prop., 2003, 26(3), 53-56.
RECENTLY INTERNATIONAL CONFERENCES
1.Li YF, Chen CY, Li B, Zhao JX, Gao YX, Zhao YL and Chai ZF. Selenium and mercury in human samples from long-term mercury- exposed populations with supplementation of selenium-enriched yeast. International Symposium on Metallomics 2007, November 28¨CDecember 1, 2007, Nagoya, Japan (Oral).
2.Li YF, Chen CY, Li B, Gao YX, Zhao YL and Chai ZF. Simultaneous speciation analysis of selenium and mercury in human urine samples from long-term mercury-exposed populations with supplementation of selenium-enriched yeast by HPLC-ICP-MS. Colloquium Spectroscopicum Internationale XXXV, September 23-27, Xiamen, China.
3.Li YF, Chen CY. A pilot study on selenium supplementation to long-term mercury-exposed populations with selenium-enriched yeast. Users and Experts¡¯ Seminar of Beijing Synchrotron Radiation Facility, August 15-17, 2007, Beijing, China. (oral)
4.Li YF, Li B, Chen CY, Sun J, Wang JX, Gao YX, Zhao YL and Chai ZF. Scalp hair as a biomarker in environmental and occupational mercury exposed populations: Suitable or not. The 9th International Conference on the Biogeochemistry of Trace Elements, July 15-19, 2007, Beijing, China. (oral)
5.Li YF, Li B, Chen CY, Sun J, Wang JX, Gao YX, Zhao YL and Chai ZF. Elimination efficiency of different reagents for the memory effect of mercury in using ICP-MS. International Symposium on Epidemiology of Toxic Metals-Problems and Solutions. April 25, 2007, Portoroz, Slovenia.
6.Chen CY, Li YF, Qu L, Li B, Wang JX, Gao YX and Chai ZF. XAFS Study on Mercury Species in Samples from Wanshan Mining Area. Users and Experts¡¯ Seminar of Beijing Synchrotron Radiation Facility, August 25-28, 2006, Hebei, China.
7.Chen CY, Li YF, Qu LY, Li B, Yu HW, Sun J, Gao YX and Chai ZF. 8th International Conference on Mercury as a Global Pollutant, August 6-11, 2006, Wisconsin, USA.
8.Chen CY, Yu HW., Gao YX, Li YF, Li B. and Chai ZF: Speciation of Trace Elements in Biological Samples by Nuclear Analytical and Related Techniques Coupled with Chemical and Biochemical Separation. June 21-25, 2006, Biao wiea, Poland.
9.Li YF, Chen CY, Sun J, Li B, Wang JX, Gao YX, Chai ZF and Zhao YL. Methods to remove external mercury contamination in human scalp hair samples from Wanshan mercury mining area. The 2nd International Symposium on Persistent Toxic Substances, May 15- 18, 2005, Beijing, China.
10.Li YF, Li B, Chen CY, Sun J, Wang JX, Gao YX, Zhao YL and Chai ZF. Elimination efficiency of different reagents for the memory effect of mercury in using ICP-MS. 2005 Asia-Pacific Symposium on Radiochemistry, October 17-21, 2005, Beijing, China.
11.Li YF, Chen CY, Liu T, Xie YN, Wang JX, Sun J, Li B, Gao YX, Zhao YL and Chai ZF. Preliminary XAFS study on interaction of metallothionein with mercuric chloride. Users and Experts¡¯ Seminar of Beijing Synchrotron Radiation Facility, July 15-19, 2005, Qingdao, China (top-five poster).
12.Li YF£¬Chen CY. Concentrations and XAFS speciation in situ of mercury in hair from populations in Wanshan mercury mine area, Guizhou. Sino-Canada Workshop on Mercury Contamination in the Environment, December 13, 2004, Beijing, China. (oral)
13.Li YF£¬Chen CY. XAFS study on mercury in hair from residents in Wanshan mercury mine area, Guizhou. Users and Experts¡¯ Seminar of Beijing Synchrotron Radiation Facility, July 2-6, 2004, Inner Mongolia, China. (oral)
Book Chapter:
Royal Society of Chemistry invited book ¡°Advanced Nuclear Analytical Techniques for Metallomics and Metalloproteomics¡±.
