PERSONAL EXPERIENCE
Graduated from Fudan University of Applied Chemistry in 1989. Got Ph.D degree from Institute of High Energy Physics, Chinese Academy of Sciences in 1998. Doctorial dissertation ˇ°Study of the Metabolism of Chromium(III) and Its Speciation in Rats by Activable Enriched Stable Isotope Techniqueˇ± gained the honor of ˇ°National Outstanding Doctoral Dissertations in 2001ˇ±. Obtained the ˇ°Young Scholar Awardˇ± awarded by the organizing committee of 1995 International Chemical Congress of Pacific Basin Societies, Honolulu, Hawaii, USAˇ±.
RESEARCH INTRODUCTION
Biological effects of nanomaterials
Nowadays, more and more nanoparticles from nanotechnological industry continue to grow and appear in environment. Since new properties usually emerge in nano-scaled particles, we are interested to know about their biological effects to biological system via direct or indirect exposure. The objective of our research is to characterize the basic interactions of nanomaterials with biological systems.
1.Evaluation of the size-dependent translocation of nanoparticles into organs.
2.Relationship between the nanobiology (including nanotoxicity) and the physical and chemical
properties of nanomaterials.
Environmental exposure and human health
Metalloprotein have been demonstrated to play an important role in living systems by being essential, toxic, mutagenic or carcinogenic. An increasing number of elements are released into the environment, while the biological effects of this exposure often remain virtually unknown. Our researches focus on the response or fate of heavy metals, such as Hg, Cr, etc. and nanoparticles in biological systems after environmental or occupational exposure.
1.Metallomics and metalloproteomics study
Investigation of the response of Hg, Fe, Cr, Cu, Zn, etc.-containing proteins to environmental exposure.
Metabonomic study of metallic exposure or metallic drug administration by HPLC-ICP-MS.
2.Analytical methodology study
Inorganic mass spectrometry (ICP-MS), organic mass spectrometry (MALDI-TOF-MS or ESI-MS/MS) and chromatography (LC, HPLC) hyphenated technique study
Distribution and quantification of metalloproteins in biological and environmental samples by isotopic tracer technique and synchrotron radiation analysis.
RECENT PUBLICATIONS
1.Mo-Tao Zhua, Wei-Yue Feng*, Bing Wang, Tian-Cheng Wang, Yi-Qun Gu, Meng Wang, Yun Wang, Hong Ouyang, Yu-LiangZhao, Zhi- Fang Chai, Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats, Toxicology, doi:10.1016/j.tox.2008.02.011.
2.Bing Wang, Weiyue Feng*, Meng Wang, Tiancheng Wang, Yiqun Gu, Motao Zhu, Hong Ouyang, Junwen Shi, Fang Zhang, Yuliang Zhao,Zhifang Chai, Haifang Wang, Jing Wang. Acute Toxicological impact of nano- and submicro-scaled zinc oxide powder on healthy adult mice, J. Nanopart. Res. 10: 263-276 (2008).
3.Meng Wang , Weiyue Feng*, Wenwei Lu, Bai Li, Bing Wang, Motao Zhu, Yun Wang, Yuliang Zhao, Zhifang Chai, Quantitative analysis of proteins via sulfur determination by HPLC coupled to isotope dilution ICP-MS with hexapole collision cell. Anal. Chem. 79: 9128-9134 (2007).
4.Wang Meng, Feng Weiyue*, Shi Junwen, Zhang Fang, Wang Bing, Zhu Motao, Li Bai, Zhao Yuliang, Chai Zhifang Development of a mild mercaptoethanol extraction method for determination of mercury species in biological samples by HPLC¨CICP-MS. Talanta 71(5): 2034-2039 (2007).
5.Junwen Shi, Weiyue Feng*, Meng Wang, Fang Zhang, Bai Li, Bing Wang Motao Zhu, Zhifang Chai. Investigation of mercury- containing proteins by enriched stable isotopic tracer and size-exclusion chromatography hyphenated to inductively coupled plasma- isotope dilution mass spectrometry. Anal. Chim. Acta, 583(1): 84-91 (2007).
6.Bing Wang, Wei-Yue Feng*, Tian-Cheng Wang, Meng Wang, Jun-Wen Shi, Fang Zhang, Yuliang Zhao, Zhi-Fang Chai, Acute toxicity of nano-and micro-scale zinc powder in healthy adult mice. Toxicol. Lett. 161, 115¨C123 (2006).
