PERSONAL EXPERIENCE
Dr. Chen graduated at Department of Chemistry, Huazhong University of Science and Technology of China and received her PhD degree in Biomedical engineering at 1996. She worked as a Postdoc at Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, CAS (1996-1998) and Medical Nobel Institute for Biochemistry of Karolinska Institute, Sweden (2001-2002). She worked as a group leader at Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences until 2006. Prof. Chen currently is a principal invesitigator at Laboratory for Bio-Enviomental Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China.
RESEARCH INTERESTS
1.Therapy for malignant tumor using nanotechnology
2. Exposure assessment for humans and the environment of superfine particles and nanomaterials
3. Public health impact of long-term exposure of heavy metals in susceptible population strata.
4. Methodology for metallomics and metalloproteomics by advanced nuclear analytical techniques
ACADEMIC AWARDS
1.¡°Excellent Doctoral Dissertation in 2001¡± rewarded by Huazhong University of Science and Technology.
2.K.C. Wong Education Foundation, Hong Kong, Award for International Conference, in 2001 and 2006, respectively.
3.Best presentation in eighth International Conference of Nuclear Analytical Methods in the Life Sciences, April 17th to 22nd of 2005, Rio de Janeiro, Brasil
4.Member of editorial board for Asian Journal of Ecotoxicology (in Chinese)
REVIEWER OF JOURNALS
1.Environmental Health Perspectives
2.Journal of Inorganic Biochemistry
3.Free Radical Biology and Medicine
4.Analytical Bioanalytical Chemistry
5.Analytica Chimica Acta
6.Journal of Radioanalytical and Nuclear Chemistry
7.Biological Trace Element Research
8.Toxicological Science
MAIN GRANTS£º
1.European sixth framework programme (FP6): Public health impact of long-term, low-level mixed element exposure in susceptible population strata (Contract no.: FOOD-CT-2006-016253, 2006-2011) one of chief scientific investigators
2.National Key Basic Research Program of China (973 Program): Health and Safety Impacts of Nanotechnology: Exploring Solutions (2006-2010), one of 7 chief scientific investigators
3.IAEA Coordinated Research Project: Exposure to mercury in women of childbearing age and its interaction with their nutritional status in typical mercury-contaminated areas of China by nuclear analytical and related techniques (2005-2008, No. 13246). chief scientific investigator
4.IUPAC project: ¡°Critical report regarding the determination of selenomethionine in selenized yeast supplements ¡± (Division V, 2005- 041-1, 2006-2007) one of participants
5.KEK photon factory cooperation project: Behaviour and Translocation of Metallic Nanoparticles in vivo using synchrotron techniques (2008G189, 2008-2009), Principal Investigator
6.KEK photon factory cooperation project: Study on the interaction between metalloproteins and toxic elements in biological systems (2006G216, 2006-2007), chief scientific investigator
7.National Natural Science Foundation of China (NNSFC) Major project: Molecular toxicology of several typical environmental pollutants by advanced nuclear analytical techniques (2004-2007), one of chief investigators
8.A major project approved by Chinese Academy of Sciences: Application of advanced nuclear analytical techniques in the environment (2001-2004), Major investigator
9.National Natural Science Foundation of China (NNSFC) project: Studies on Species of Selenium in Human Livers and hepatoma Specimen (2001-2003), chief investigator
REPRESENTATIVE PUBLICATIONS
1.Wei Li, Chunying Chen*, Chang Ye, Taotao Wei*, Yuliang Zhao*, Fang Lao, Zhen Chen, Huan Meng, Yuxi Gao, Hui Yuan, Gengmei Xing, Feng Zhao, Zhifang Chai, Xujia Zhang, Fuyu Yang, Dong Han, Xianhua Tang, Yingge Zhang, The translocation of Fullerenic nanoparticles into Iysosome via the pathway of clathrin-mediated endocytosis. Nanotechnology 2008, 19: doi:10.1088/0957- 4484/19/14/145102. (* Corresponding author)
2.Jiangxue Wang, Chunying Chen*, Yufeng Li, Wei Li, Yuliang Zhao. Biological effect of intranasally instilled titanium dioxide nanoparticles on female mice. NANO: Brief Reports and Reviews, 2008, Accepted
3.Yu-Feng Li, Chunying Chen*, Bai Li, Wei Li, Liya Qu, Zeqin Dong, Masaharu Nomura, Yuxi Gao, Jinxuan Zhao, Yuliang Zhao, Zhifang Chai. Mercury in Human Hair and Blood Samples from Wanshan Mercury Mine Area, Guizhou, China: an XAS Study. Journal of Inorganic Biochemistry, 2008, 102/3: 500-506
4.Yu-Feng Li, Chunying Chen,* Bai Li, Qing Wang, Jiangxue Wang, Yuxi Gao, Yuliang Zhao and Zhifang Chai* Simultaneous speciation of selenium and mercury in human urine samples from long-term mercury-exposed populations with supplementation of selenium- enriched yeast by HPLC-ICP-MS, J. Anal. At. Spectrom., 2007, 22, 925 ¨C 930.
5.Yuxi Gao, Chunying Chen, Zhifang Chai. Advanced nuclear analytical techniques for metalloproteomics, J. Anal. At. Spectrom., 2007, 22, 856-866. Invited Review
6.Huan Meng, Zhen Chen, Gengmei Xing, Hui Yuan, Chunying Chen, Feng Zhao, Chengcheng Zhang, Yuliang Zhao, Ultrahigh reactivity provokes nanotoxicity: Explanation of oral toxicity of nano-copper particles. Toxicology Letters 2007, 175(1-3): 102-110.
7.Yufeng Li, Chunying Chen*, Bai Li, Jin Sun, Jiangxue Wang, Yuxi Gao, Yuliang Zhao and Zhifang Chai. Elimination efficiency of different reagents for the memory effect of mercury in using ICP-MS. J. Anal. Atomic Spect, 2006, 21(1), 94-96.
8.Chunying Chen*, Hongwei Yu, Jiujiang Zhao, Bai Li, Liya Qu, Shuiping Liu, Peiqun Zhang, Zhifang Chai. The roles of serum selenium and selenoproteins upon mercury toxicity in environmental and occupational exposure. Environmental Health Perspectives, Mini- monograph. 114(2):297-301, 2006
9.Jiangxue Wang, Chunying Chen*, Bai Li, Hong Wei Yu, Yu Liang Zhao, Jin Sun, Yu Feng Li, Geng Mei Xing, Hui Yuan, Jun Tang, Zhen Chen, Huan Meng, Yu Xi Gao, Chang Ye, Zhi Fang Chai, Chuanfeng Zhu, Baocheng Ma, Xiaohong Fang, Lijun Wan. Antioxidative Function and Biodistribution of [Gd@C82(OH)22]n Nanoparticles in tumor-bearing mice. Biochem Pharm. 2006, 2006, 71: 872£881
10.Zhiyong Zhang, Chunying Chen, Weiyue Feng and Zhifang Chai*. Isotopic Tracer Studies on the Metabolism and Functional Roles of Mineral Elements in Institute of High Energy Physics, China. Journal of Nuclear Science and Technology, 2006, 43, No. 4, p. 1-5.
11.Chunying Chen*, Jiujiang Zhao, Liya Qu, Guilong Deng, Peiqun Zhang and Zhifang Chai. Cellular distribution of mercury, selenium and their binding proteins in kidney and liver of pigs from mercury-exposed areas with the investigation of their redox responses. Science of Total environment, 2006, 366 (2-3): 627-637
12.Chunying Chen, Liya Qu, Bai Li, Guang Jia, Xing Li, Peiqun Zhang, Yuxi Gao, Mei Li, Wei Chen, Zhifang Chai. Increased Oxidative DNA Damage (Urinary 8-Hydroxydeoxyguanosine Content) And Redox Status Among Subjects Exposed To Mercury. Clinical Chemistry 2005, 51(4): 759-767.
13.Chunying Chen, Gengmei Xing, Jiangxue Wang, Yuliang Zhao, Bai Li, Guang Jia, Tiancheng Wang, Jin Sun, Li Xing, Hui Yuan, Yuxi Gao, Chang Ye, Zhifang Chai. Multihydroxylated [Gd@C82(OH)22] n Nanoparticles: Antineoplastic Activity of High Efficiency and Low Toxicity. Nano Letter 2005, 5(10): 2050-2057.
14.Yuxi Gao, Yingbin Liu, Chunying Chen, Bai Li, Wei He, Yuying Huang, Zhifang Chai. Combination of synchrotron radiation X-ray fluorescence with isoelectric focusing for study of metalloprotein distribution in cytosol of hepatocellular carcinoma and surrounding normal tissues, J. Anal. At. Spectrom. 2005, 20:473-475.
15.Peiqun Zhang, Chunying Chen *, Milena Horvat, Radojko Ja?imovi?, Ingrid Falnoga, Bai Li, Jiujiang Zhao, Zhifang Chai. Element content and element correlations in Chinese human liver. Anal Bioanal Chem, 2004, 380: 773-781
16.Linda Johansson, Chunying Chen, Jan-Olov Thorel, Anna Fredriksson, Sharon Stone-Elander, Guro Gafvelin and Elias S. J. Arn¨¦r. Exploiting the 21st amino acid ¡ª Purifying and labeling recombinant proteins by selenolate targeting, Nature Methods, 2004, 1, 61- 66.
RECENTLY INTERNATIONAL CONFERENCES
1.CHEN Chunying, Cytotoxicity and Genotoxicity Assessment:Are their Mechanisms Correlated with Properties of Engineered Nanoparticles?2nd International Conference on Nanotoxicology,September 7¨C10,2008, Zurich,Switzerland (invited speaker)
2.CHEN Chunying, Mercury-binding species related to human health,involvement of selenium and metallothioneins,Georgian Bay International Conference on Bioinorganic Chemistry,2007.5.23-27, Parry Sound,Ontario,Canada.(invited speaker)
3.CHEN Chunying, Potential Neurotoxicity of Nasal Instilled TiO2 nanoparticles.International Symposium of nanotechnology in Environmental Pollution and Protection,2007.12.11-13, Fort Lauderdale,USA. (keynote speaker)
4.Chen Chunying, Localization and Biodistribution of Metallic Nanoparticles in Organisms Using Microbeam SRXRF Mapping Techniques and ICP-MS.Colloquium Spectroscopicum Internationale XXXV,2007.09.23-27,Xiamen, China.
5.Chen Chunying, Translocation of Inhaled TiO2 nanoparticles into the Central Nervous System associated with potential damage on murine brain.International Conference on Nanotoxicology.2007.04.19-22,Venice,Italy.
Book Chapter:
1.Chen CY, Chai ZF, Gao YX, coeditors. Book title: Advanced Nuclear Analytical Techniques for Metallomics and Metalloproteomics, The Royal Society of Chemistry, RSC Publishing, in preparation.
2.Wang JX, Chen CY*. Environmental health and ecotoxicology effects of nanoscale titanium dioxide (MS number 646), in ENCYCLOPEDIA OF ENVIRONMENTAL HEALTH, Edited by Jerome Nriagu, Elsevier limited. Invited book chapter, under review.
3.Chen CY, Chapter 9: Introduction to HPLC-ICP-MS hyphenated techniques and their application in elemental speciation, in Book ¡°Advanced Instrumental Analysis and Techniques¡± edited by Xiaomei Ling, Peking University Medical Press (PUMP), 2006 .
4.Chen CY, He HY. Chapter 12: Selenium in Environment, in Book ¡°Selenium: Chemistry, Biochemistry and its application in Life Science¡±, Edited by Huibi Xu and Kaixun Huang, Huazhong University of Science and Technology, 1994, 268-283. The 2nd version is under review.
5.Liu Q, Chen CY, He HY. Chapter: Analytical Chemistry for Selenium, in Book ¡°Selenium: Chemistry, Biochemistry and its application in Life Science¡±, Edited by Huibi Xu and Kaixun Huang, Huazhong University of Science and Technology, the 2nd version is under review.
PATENT
1.Chunying Chen, Yan Jiang, Jinyan Zhou, Yiming Shao, Huibi Xu, Lijuan Pei, Sulfation of Polysaccharides Isolated from Indocalamus Tesselatus and their anti-HIV Activity, in Invention Patent of China, China Patent Office, China (in Chinese), CN1193023A, ZL 98 1 01638.3.
2.Yuliang Zhao, Chunying Chen, Gengmei Xing. Metallofullerol and their applications for preparation of medicine for inhibition of tumor growth. (Application No: 200510103494.7, PCT/CN2006/002405)
3.Chunying Chen,Yuliang Zhao, Chang Ye, Fang Jiao, Wei Li. Water-soluble Fullerene derivatives, composite and their application in the preparation of medicine for Inhibition of tumor growth and distant metastasis (Application No: 200710175456.1, in Chinese)
Current Lab Members:
Principal Investigator:
Dr. Chunying CHEN
Technicians:
Ms. Ru BAI, master's degree
Postdoc:
Dr. Ying LIU
Ph.D candidates:
Wei Li
Fang JIAO
Guoqiang ZHOU
Cuicui GE
Fang LAO
Lili ZHANG
Liming WANG
Graduate students:
Yang QIU
Ying Qu
